Dysphoria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dysphoria (from Greek δύσφορος (dysphoros), from δυσ-, difficult, and φέρω, to bear) is generally characterized as an unpleasant or uncomfortable mood, such as sadness (depressed mood), anxiety, irritability, or restlessness.^[1] Etymologically, it is the opposite of euphoria.

Dysphoria refers only to a condition of mood and may be experienced in response to ordinary life events, such as illness or grief. Additionally, it is a feature of many psychiatric disorders, including anxiety disorders and mood disorders. Dysphoria is usually experienced during depressive episodes, but in people with bipolar disorder, it may also be experienced during manic or hypomanic episodes.^[2] Dysphoria in the context of a mood disorder indicates a heightened risk of suicide.^[2]

Dysphoria can be chemically induced by substances including mu-opioid antagonists^[3] and selective kappa-opioid agonists.^[4] Dysphoria is also one of the symptoms of hypoglycemia.

• Drug side effect: Butorphanol, Hydrocodone bitartrate and acetaminophen

The following conditions may include dysphoria as a major component or symptom.

• Clinical depression (unipolar) and dysthymia
• Premenstrual Syndrome
• Bipolar disorder^[2]
• General anxiety disorder
• Gender identity disorder, sometimes called gender dysphoria
• Personality disorders such as borderline personality disorder and avoidant personality disorder
• Substance withdrawal
• Body dysmorphic disorder
• Hypoglycemia

“Dysphoria” is also the name of an alternative-rock band based in Alexandria, Virginia. Band members include Kyle Lynn and Blair Hicks.

• Abbess, John F. “Glossary of terms in the field of psychiatry and neurology”. Retrieved 2006-11-18.
• “Dysphoria.” Alleydog.com Psychology Glossary.
• Metcalf, Matthew (2005). “Kappa Opioid Antagonists: Past Successes and Future Prospects”. The AAPS Journal. American Association of Pharmaceutical Scientists. 7 (3): E704–E722. ISSN 1522-1059. Retrieved 2006-11-19. Unknown parameter |coauthors= ignored (help)
• Read, Kimberly (2006). “What is dysphoria?”. Your Guide to Bipolar Disorder. About.com. Retrieved 2006-11-19.

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