Endometrial cancer classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:^[1]

Type	Histology	Prognosis	Pathogenesis	Prevalence
Type I	Endometroid (adenocarcinoma)	Favorable (estrogen-responsive)	• May arise from atypical hyperplasia • Linked to unopposed estrogen stimulation	80%
Type II	• Endometroid • Serous • Clear cell • Mucinous • Squamous • Mesonephric • Undifferentiated	Typically bad prognosis	• Develops from atrophic endometrium • Not linked to hormonally driven pathogenesis	15-20%

References

↑ Bokhman JV (1983). “Two pathogenetic types of endometrial carcinoma”. Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

Template:WikiDoc Sources

[pmid6822361-1] Bokhman JV (1983). “Two pathogenetic types of endometrial carcinoma”. Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

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