FZD5
Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]
Members of the ‘frizzled’ gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3]
See also
References
- ↑ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). “A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
- ↑ Saitoh T, Hirai M, Katoh M (Jun 2001). “Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region”. Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.
- ↑ 3.0 3.1 “Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)”.
External links
- “Frizzled Receptors: FZD5“. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- He X, Saint-Jeannet JP, Wang Y, et al. (1997). “A member of the Frizzled protein family mediating axis induction by Wnt-5A”. Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360.
- Finch PW, He X, Kelley MJ, et al. (1997). “Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Tanaka S, Akiyoshi T, Mori M, et al. (1998). “A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- Tamai K, Semenov M, Kato Y, et al. (2000). “LDL-receptor-related proteins in Wnt signal transduction”. Nature. 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Yao R, Maeda T, Takada S, Noda T (2001). “Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled”. Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Weidler C, Schaumburger J, Miller LE, et al. (2004). “Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation”. J. Rheumatol. 31 (9): 1874–5. PMID 15338479.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). “Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
- Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). “Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein”. Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). “Generation and annotation of the DNA sequences of human chromosomes 2 and 4”. Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Blumenthal A, Ehlers S, Lauber J, et al. (2006). “The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation”. Blood. 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243.
- Yamamoto H, Komekado H, Kikuchi A (2006). “Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin”. Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.
- Katoh Y, Katoh M (2007). “Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer”. Int. J. Oncol. 30 (3): 751–5. doi:10.3892/ijo.30.3.751. PMID 17273778.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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