Factor XIII deficiency

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Factor XIII deficiency may occur very rarely, and can cause a severe bleeding tendency. Incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit. Administration of recombinant A subunit improves clot stability and may become a therapeutic option for patients with this condition^[1].

References

↑ Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, Blain R, Pederson S, Ishak L, Nugent D (2006). “Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency”. Blood. 108 (1): 57–62. PMID 16556896.

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[1] Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, Blain R, Pederson S, Ishak L, Nugent D (2006). “Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency”. Blood. 108 (1): 57–62. PMID 16556896.

[1]

Factor XIII deficiency

Overview

See also

References