Familial amyloidosis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Laboratory findings in amyloidosis include elevated erythrocyte sedimentation rate, increased BUN level, serum creatinine, protein, casts, or fat cast in urine. Serum troponin, B-type natriuretic peptide, and beta-2-microglobulin are prognostic markers for heart failure. We may also have elevated level of AST, ALT, bilirubin, ALP, and TSH.

Cardiac

• Cardiac biomarkers are the most important predictors of outcome in amyloidosis. They provide a quantitative assessment for cardiac damage and wall strain.^[1][2][3]

• Troponin I or Troponin T
• BNP and NT-proBNP

Hepatic

• Common tests that are abnormal in liver function tests including:

• AST
• ALT
• Total bilirubin
• Alkaline phosphatase
• Albumin

Renal

• Common tests that are abnormal in renal function tests including:

• Serum creatinine
• Urinary protein
• Glomerular filtration rate
• Albumin to creatinine ratio in the urine

Thyroid

• Common tests that are abnormal in thyroidal involvement of amyloidosis include:

• TSH
• Free T4

Template:WH Template:WS