Familial mediterranean fever causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Familial Mediterranean fever is most often caused by a mutation in the MEFV gene. This gene creates proteins involved in inflammation. There are also reports of FMF cases in the absence causative gene in the genetic screening.
Causes
- Familial Mediterranean fever is caused by a mutation in the MEFV gene.[1]
- There are reported cases of FMF in the absence of known genetic mutation in their genetic analysis. These studies explain that, in these cases, either mutation occurred in non-coding region or the disease were developed due to unknown causes.[2]
References
- ↑ “A candidate gene for familial Mediterranean fever”. Nat. Genet. 17 (1): 25–31. September 1997. doi:10.1038/ng0997-25. PMID 9288094.
- ↑ Cekin, Nilgun; Akyurek, Murat Eser; Pinarbasi, Ergun; Ozen, Filiz (2017). “MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever”. Gene. 626: 9–13. doi:10.1016/j.gene.2017.05.013. ISSN 0378-1119.
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