Fibroma medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

The majority treatment of cases of fibromas is not medical therapy, but for some one’s such as uterine fibroma does have medical therapy.Medical therapy depends on the type of fibroma.

The majority treatment of cases of fibromas is not medical therapy, but for some one’s such as uterine fibroma does have medical therapy.^{[1][2][3][4][5][6][7][8]}

• At present, there are no definitive agents for long-term medical treatment of uterine fibroma approved by Food and Drug Administration (FDA). But however, there are some agents that can be used in the management of this common benign tumor.^{[1][2][3][4][5][6][7][8]}

• Gonadotropin-releasing hormone analogues can effectively reduce uterine leiomyoma volume, menorrhagia(heavy menstrual bleeding), and also stabilize hemoglobin levels by inducing an iatrogenic reversible menopause.
• Some of them are Leuprolide, Buserelin, Nafarelin, Deslorelin, Histrelin, Goserelin, Tryptorelin
• Effects of GnRH agonists are temporary, and re-growth has been reported in many cases of leiomyomas to their pretreatment sizes after stopping them.

• Commonly used add-back agents are progestins alone, estrogen alone, combined estrogen and progesterone, tibolone, and raloxifene.
• To overcome the unwanted side effects and maintaining the benefits of GnRH therapy add-back therapy is commonly used.

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