Fifth disease physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Physical Examination
Skin
Bright red cheeks are a defining symptom of the infection in children (hence the name “slapped cheek disease”). Occasionally the rash will extend over the bridge of the nose or around the mouth. In addition to red cheeks, children often develop a red, lacy rash on the rest of the body, with the upper arms and legs being the most common locations.

Gallery
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Note the left side of this boy’s face displaying signs of erythema infectiosum, or Fifth disease. From Public Health Image Library (PHIL). [2]
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Fifth disease. From Public Health Image Library (PHIL). [2]
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Image depicts the upper back and arms of a young girl who’d been diagnosed with a case of erythema infectiosum, or Fifth disease. From Public Health Image Library (PHIL). [2]
References
© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH

![Note the left side of this boy’s face displaying signs of erythema infectiosum, or Fifth disease. From Public Health Image Library (PHIL). [2]](https://www.wikidoc.org/images/a/a3/Erythema_infectiosum04.jpeg)
![Fifth disease. From Public Health Image Library (PHIL). [2]](https://www.wikidoc.org/images/1/12/Erythema_infectiosum03.jpeg)
![Image depicts the upper back and arms of a young girl who’d been diagnosed with a case of erythema infectiosum, or Fifth disease. From Public Health Image Library (PHIL). [2]](https://www.wikidoc.org/images/3/35/Erythema_infectiosum01.jpeg)