Focal segmental glomerulosclerosis natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]

• The symptoms of focal segmental glomerulosclerosis usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
• The symptoms of (disease name) typically develop ___ years after exposure to ___.
• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Common complications of focal segmental glomerulosclerosis include:^[1]

• End stage renal disease
• Malnutrition
• Infections
• Nephrotic syndrome

• There are several clinical and pathological features which predict the outcome.
• Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:^[2][3]:
  • Black race
  • Increased degrees of proteinuria
  • renal insufficiency
  • Increased severity of interstitial fibrosis
  • Tubular atrophy in biopsy specimens

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