Gallbladder cancer historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

In 1777 Maxmillan de Stol described the gallbladder cancer and since studies have established in the identification of the disease and ineffective treatment of this disease.Gallbladder cancer(GBC) are often clinically asymptomatic and an surprising finding at incision, most commonly detected incidentally on histological examination.GBC is characterised by local invasion, intensive regional lymphoid tissue metastasis and distant metastases. In general, GBC is that the most aggressive of the biliary cancers with the shortest median survival period.

• In between 1922 –1956, 4,271 cholecystectomy samples were collected and adenocarcinomas were noted.^[1]
• In between 1962–1999, Stephen et al was to discover the association between calcium deposits and the development of gallbladder cancer is 7%.

• The association between calcium deposits in the gall bladder and the gallbladder cancer was made during 1797.^[2][3][4]
• Current literature evaluation shows that the general occurrence of Porcelain gallbladder cancer, and gallbladder cancer most cancers is 0.2% and 0.8%, respectively—with a 15% concomitant occurrence.

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