Gestational trophoblastic neoplasia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]

Gestational trophoblastic neoplasia patients can present with history of previous pregnancies including hydatidiform mole (molar pregnancy) and miscarriage, history of previous gestational trophoblastic disease (GTD), and signs and symptoms that may suggest gestational trophoblastic disease (GTD). Symptoms of choriocarcinoma include vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, and abdominal distension.

When obtaining history from a patient with suspected gestational trophoblastic neoplasia, specific areas of focus include:

• History of previous pregnancies, including hydatidiform mole (molar pregnancy) and miscarriage
• History of previous gestational trophoblastic disease (GTD)
• Reproductive factors that may increase the risk of gestational trophoblastic disease (GTD)
• A family history of gestational trophoblastic disease (GTD)
• Signs and symptoms that may suggest gestational trophoblastic disease (GTD)

• Vaginal bleeding^[1]
• Nausea and vomiting
• Passing of tissue resembling a “bunch of grapes” from the vagina
• Absent fetal movement during pregnancy
• Abdominal distension

• Headache
• Edema of the hands and feet
• Abdominal or pelvic pain
• Vaginal discharge
• Overactive thyroid gland (hyperthyroidism) that causes:

• Tachycardia
• Sweating
• Shaking
• Heat intolerance
• Fever

• Hemoptysis
• Dry cough
• Chest pain
• Trouble breathing
• Headache
• Dizziness
• Jaundice
• Paralysis
• Seizure
• Dysarthria and dysphasia
• Vision problems
• Lump in the vagina

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