Glanzmann's thrombasthenia physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH

Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses, petechiae and purpura or current bleeding on physical exam.

Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses, petechiae and purpura or current bleeding on physical exam.^{[1][2][3][4][5][6][7][8]}

• Patient appears well in the absence of severe hemorrhage
• Patient appears ill in the persistent bleeding

• Tachycardia, depending on the severity of the bleeding
• Tachypnea depending on severity of the bleeding

• Cyanosis
• Pallor
  • Secondary to anemia
• Ecchymoses,petechiae and purpura
  • Secondary to thrombocytopenia

• Evidence of trauma
• Pale conjunctiva
• Epistaxis
• Palatal petechiae
• Gingival or other oral cavity bleeding

No specific signs

• Commonly normal lung sounds

• Commonly normal heart sounds

The spleen is usually non palpable

• Patient is usually oriented to persons, place, and time
• Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes ^[9]

• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]
• 
  Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[10]