Glucose-6-phosphate dehydrogenase deficiency classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

G6PD deficiency may be classified to into 5 subtypes and gives some approximation of the magnitude of hemolysis an individual may incur in the setting of an oxidative stress.

G6PD deficiency may be classified according to World Health Organization into 5 subtypes: ^[1][2]

• Class I: Severe deficiency (<10% activity) with chronic hemolytic anemia.
• Class II: Severe deficiency (<10% activity), with intermittent hemolysis. G6PD Mediterranean deficiency is a class II deficiency.
• Class III: Moderate deficiency (10-60% activity), hemolysis with significant oxidant stress. G6PD A- deficiency is a class III deficiency.
• Class IV: No enzyme deficiency or hemolysis, no clinical sequelae. it has G6PD B, normal wild-type enzyme
• Class V: Increased enzyme activity (more than twice normal), no clinical sequela

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