Glucose-6-phosphate dehydrogenase deficiency other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Other diagnostic studies for G6PD deficiency include CBC, Lactate dehydrogenase, Haptoglobin, Urinalysis, Peripheral blood smear.

Other Diagnostic Studies

G6PD deficiency is suspected in patients with positive family history who develop jaundice and anemia after exposure to any causes. Other diagnostic studies include:^[1]^[2]

CBC and reticulocyte count (increased reticulocyte count in G6PD deficiency)
Lactate dehydrogenase: increased in hemolysis
Haptoglobin: decreased in hemolysis
Urinalysis: hematuria
Coombs test (direct antiglobulin test): negative in G6PD deficency
Liver enzymes for rulling out other causes of jaundice
Urinary hemosiderin
Peripheral blood smear: Heinz bodies (denatured hemoglobin)
G6PD screen: to assess for the mutation or defect at the genomic level

References

↑ Frank JE (October 2005). “Diagnosis and management of G6PD deficiency”. Am Fam Physician. 72 (7): 1277–82. PMID 16225031.
↑ Frank JE (October 2005). “Diagnosis and management of G6PD deficiency”. Am Fam Physician. 72 (7): 1277–82. PMID 16225031.

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[pmid16225031-1] Frank JE (October 2005). “Diagnosis and management of G6PD deficiency”. Am Fam Physician. 72 (7): 1277–82. PMID 16225031.

[pmid162250312-2] Frank JE (October 2005). “Diagnosis and management of G6PD deficiency”. Am Fam Physician. 72 (7): 1277–82. PMID 16225031.

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