Glucose-6-phosphate dehydrogenase deficiency physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [3]

Overview

Patients with G6PD deficiency usually appear normal. Physical examination of patients with G6PD deficiency is usually remarkable for jaundice in hemolysis and abdominal tenderness in the right upper abdominal quadrant because of hyperbilirubinemia.

Physical Examination

Physical examination of patients with G6PD deficiency is usually normal.

Appearance of the Patient

Patients with G6PD deficiency usually appear normal.

Vital Signs

Tachycardia in acute hemolysis
Tachypnea due to anemia

Skin

Jaundice in hemolysis ^[1]
Pallor

HEENT

HEENT examination of patients with G6PD deficiency is usually normal

Neck

Neck examination of patients with G6PD deficiency is usually normal

Lungs

Pulmonary examination of patients with G6PD deficiency is usually normal

Heart

Cardiovascular examination of patients with G6PD deficiency is usually normal

Abdomen

Abdominal distention
Abdominal tenderness in the right upper abdominal quadrant because of hyperbilirubinemia and cholelithiasis^[2]
Splenomegaly maybe in severe hemolysis

Genitourinary

Dark urine
Genitourinary examination of patients with G6PD deficiency is usually normal

Neuromuscular

Neuromuscular examination of patients with G6PD deficiency is usually normal

Extremities

Extremities examination of patients with G6PD deficiency is usually normal

References

↑ Luzzatto L, Arese P (January 2018). “Favism and Glucose-6-Phosphate Dehydrogenase Deficiency”. N. Engl. J. Med. 378 (1): 60–71. PMID 29298156.
↑ Arese P, Gallo V, Pantaleo A, Turrini F (October 2012). “Life and Death of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficient Erythrocytes – Role of Redox Stress and Band 3 Modifications”. Transfus Med Hemother. 39 (5): 328–34. doi:10.1159/000343123. PMC 3678266. PMID 23801924.

Template:WH Template:WS

[pmid29298156-1] Luzzatto L, Arese P (January 2018). “Favism and Glucose-6-Phosphate Dehydrogenase Deficiency”. N. Engl. J. Med. 378 (1): 60–71. PMID 29298156.

[pmid23801924-2] Arese P, Gallo V, Pantaleo A, Turrini F (October 2012). “Life and Death of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficient Erythrocytes – Role of Redox Stress and Band 3 Modifications”. Transfus Med Hemother. 39 (5): 328–34. doi:10.1159/000343123. PMC 3678266. PMID 23801924.

[1]

[2]