Gonadoblastoma historical perspective
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma was first discovered by Dr. Scully in 1953. The association between GBY gene (GonadoBlastoma on the Y chromosome) and gonadoblastoma was made in 1986. In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including Testis-specific protein Y-encoded (TSPY) gene.
Historical Perspective
- Gonadoblastoma was first discovered by Dr. Scully, an American pathologist, in 1953 studying the pathology of a series of tumors suspected of being dysgerminomas.[1][2][3][4]
- This tumor is called gonadoblastoma since it looks like embryonic tissue, but in an indifferent way regarding sexual development.
- The association between GBY gene (GonadoBlastoma on Y chromosome) and gonadoblastoma was made in 1986.
- In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including testis-specific protein Y-encoded (TSPY) gene.
References
- ↑ Scully, Robert E. (1953). “Gonadoblastoma. A gonadal tumor related to the dysgerminoma (Seminoma) and capable of sex-hormone production”. Cancer. 6 (3): 455–463. doi:10.1002/1097-0142(195305)6:3<455::AID-CNCR2820060303>3.0.CO;2-U. ISSN 0008-543X.
- ↑ Scully RE (1970). “Gonadoblastoma. A review of 74 cases”. Cancer. 25 (6): 1340–56. PMID 4193741.
- ↑ Page DC (1987). “Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads”. Development. 101 Suppl: 151–5. PMID 3503713.
- ↑ Tsuchiya K, Reijo R, Page DC, Disteche CM (December 1995). “Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome”. Am. J. Hum. Genet. 57 (6): 1400–7. PMC 1801429. PMID 8533770.
© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH