Goodpasture syndrome other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

Other diagnostic studies for Goodpasture syndrome include renal biopsy. In patients with inconclusive lab and imaging findings, renal biopsy remains the gold standard in establishing the presence of Goodpasture syndrome. A renal biopsy can also identify the severity of disease and guide medical therapy.

Other Diagnostic Studies

Other diagnostic studies for Goodpasture syndrome include renal biopsy.^[1]
In patients with inconclusive lab and imaging findings, renal biopsy remains the gold standard in establishing the presence of Goodpasture syndrome. However, it may be observed renal biopsy is preferred over pulmonary biopsy because of abundance of autofluorescence. In patients where renal biopsy is not an option transbronchial or open lung biopsy may be performed.^[2]
Percutaneous kidney biopsy is the preferred route of procedure.
Renal biopsy helps establish the histopathological evidence of anti-glomerular basement membrane antibodies.
Renal biopsy can help identify the early focal proliferative changes in glomeruli which leads to inflammation, necrosis and crescent formation
Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen around the glomerular basement membrane. ^[3]

References

↑ Alenzi FQ, Salem ML, Alenazi FA, Wyse RK (2012). “Cellular and molecular aspects of Goodpasture syndrome”. Iran J Kidney Dis. 6 (1): 1–8. PMID 22218111.
↑ Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003). “Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen”. N Engl J Med. 348 (25): 2543–56. doi:10.1056/NEJMra022296. PMID 12815141.
↑ Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.

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[pmid22218111-1] Alenzi FQ, Salem ML, Alenazi FA, Wyse RK (2012). “Cellular and molecular aspects of Goodpasture syndrome”. Iran J Kidney Dis. 6 (1): 1–8. PMID 22218111.

[pmid12815141-2] Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003). “Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen”. N Engl J Med. 348 (25): 2543–56. doi:10.1056/NEJMra022296. PMID 12815141.

[pmid25462583-3] Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.

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