HELLP syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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The only effective treatment is delivery of the baby. Several medications have been investigated for the treatment of HELLP syndrome, but evidence is conflicting as to whether magnesium sulfate decreases the risk of seizures and progress to eclampsia. The DIC is treated with fresh frozen plasma to replenish the coagulation proteins, and the anemia may require blood transfusion. In mild cases, corticosteroids and antihypertensives (labetalol, hydralazine, nifedipine) may be sufficient. Intravenous fluids are generally required.

• The main treatment is to deliver the baby as soon as possible, even if the baby is premature.
• Problems with the liver and other complications of HELLP syndrome can quickly get worse and be harmful to both the mother and child.
• Induction of labor by giving drugs to start labor, or a C-section.
• One may also receive:

• A blood transfusion if bleeding problems become severe
• Corticosteroid medications to help the baby’s lungs develop faster
• Medications to treat high blood pressure

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