HLA-A66

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

HLA-A66 (A66) is an HLA–A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[1] A66 is more common in Africa and SW Europe. A66 is uncommon.

Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products^[2]
A*66	A66	A10	A26	Other	Sample
allele	%	%	%	%	size (N)
6601	20	10	61	3	799
6602	38	10	4	31	205
6603	32	7	7	18	28

A*6601 Frequencies

HLA A*6601 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Sawa	7.7
^[3]	Kenya Luo	6.8
^[3]	Cameroon Sawa	7.7
^[3]	Cameroon Bakola Pygmy	5.8
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Kenya Nandi	5.0
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Cameroon Baka Pygmy	5.0
^[3]	Cameroon Beti	4.6
^[3]	Cameroon Bamileke	4.5
^[3]	India West Bhils	4.0
^[3]	Zimbabwe Harere Shona	3.8
^[3]	Uganda Kampala	3.8
^[3]	India Mumbia Marathas	2.5
^[3]	Cape Verde Northwestern	2.5
^[3]	Czech republic	2.4
^[3]	Morocco Nador Metalsa	2.1
^[3]	Central Portugal	2.0
^[3]	India West Parsis	2.0
^[3]	South Africian Natal Zulu	2.0
^[3]	Kenya	1.7
^[3]	Tunisia Tunis	1.7
^[3]	Guinea Bissau	1.5
^[3]	Georgia Tibilisi	1.4
^[3]	Zambia Lusaka	1.2
^[3]	Italy Bergamo	1.1
^[3]	Pakistan Karachi Parsi	1.1
^[3]	Oman	0.8
^[3]	Sudanese	0.8
^[3]	Belgium	0.5
^[3]	Southeast France	0.4
^[3]	Mongolia Buriat	0.4
^[3]	Wales	0.2

HLA A*6602 frequencies
		freq
ref.	Population	(%)
^[3]	South Africian Natal Zulu	1.5
^[3]	Cameroon Yaounde	1.1
^[3]	Cameroon Bamileke	0.6
^[3]	Senegal Niokholo Mandenka	0.5
^[3]	Kenya Nandi	0.4
^[3]	Zimbabwe Harare Shona	0.2
^[3]	Wales	0.03
HLA A*6603 frequencies
		freq
ref.	Population	(%)
^[3]	Cameroon Pygmy Baka	10.0
^[3]	Cameroon Bakola Pygmy	9.0
^[3]	Cameroon Sawa	7.7
^[3]	CAR Mbenzele Pygmy	2.8
^[3]	Zimbabwe Harare Shona	0.2

References

↑ Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). “Structural diversity in the HLA-A10 family of alleles: correlations with serology”. Tissue Antigens. 41 (2): 72–80. PMID 8475492.
↑ derived from IMGT/HLA
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 ^3.22 ^3.23 ^3.24 ^3.25 ^3.26 ^3.27 ^3.28 ^3.29 ^3.30 ^3.31 ^3.32 ^3.33 ^3.34 ^3.35 ^3.36 ^3.37 ^3.38 ^3.39 ^3.40 ^3.41 ^3.42 ^3.43 ^3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)

Template:WikiDoc Sources

[pmid8475492-1] Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). “Structural diversity in the HLA-A10 family of alleles: correlations with serology”. Tissue Antigens. 41 (2): 72–80. PMID 8475492.

[2] rived from IMGT/HLA

[pmid12753660-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 ^3.22 ^3.23 ^3.24 ^3.25 ^3.26 ^3.27 ^3.28 ^3.29 ^3.30 ^3.31 ^3.32 ^3.33 ^3.34 ^3.35 ^3.36 ^3.37 ^3.38 ^3.39 ^3.40 ^3.41 ^3.42 ^3.43 ^3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)

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