Hamartoma history and symptoms
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Vamsikrishna Gunnam M.B.B.S [3]
Overview
Hamartomas are usually asymptomatic. However, in some cases such as hypothalamic hamartomas and pulmonary hamartomas, symptoms may be more noticeable. Common symptoms of hypothalamic hamartomas include seizures, visual problems, early onset of puberty, and behavioral problems. Symptoms of pulmonary hamartoma may result from respiratory obstruction and include chronic cough, hemoptysis, or fever. It is important to obtain the history about familial inheritance, as it provides insight into the associated conditions.
History and Symptoms
Obtaining the history is an important aspect of making the diagnosis of inherited hamartomatous syndromes. It provides insight into the cause, and associated conditions. Complete family history can help determine the prognosis. Specific histories about the associated symptoms should be obtained. Specific areas of focus when obtaining the history, are outlined below:
History
Family history for other inherited hamartomatous syndromes
- Familial juvenile polyposis syndrome
- Cowden’s syndrome
- Bannayan-Ruvalcaba-Riley syndrome
- Peutz-Jeghers syndrome
- Basal cell nevus syndrome
- Neurofibromatosis 1
- Multiple endocrine neoplasia syndrome 2B
Symptoms
The majority of patients with hamartomas are asymptomatic.
Common Symptoms
- Gelastic seizures have a typically of short duration (2-30 seconds) and are characterized by uncontrollable laughter, without impairment of consciousness, where as frontotemporal gelastic seizure are usually longer lasting and can result in loss of consciousness. Very rarely children with hypothalamic hamartomas can enter into status gelasticus.[1]
- Visual deficit
- Early onset of puberty
- Behavioural changes
- Respiratory obstruction
- Chronic cough
- Hemoptysis
- Fever
- Chest pain
- Palpitations
- Dyspnea on exertion[2]
- Shortness of breath
Less Common Symptoms
Less common symptoms of hamartomas include[3][4][5][6]
Kidney, spleen and other vascular organs include
- Flank pain
- Abdominal pain
- Growth retardation
- Recurrent infections
- Fever
- Night sweats[3]
References
- ↑ Hypothalamic hamartoma. Dr Donna D’Souza et al. Radiopedia.http://radiopaedia.org/articles/pulmonary-hamartoma-1 Accessed on December 09, 2015
- ↑ Raffa GM, Malvindi PG, Settepani F, Melotti F, Monti L, Spaggiari P, Basciu A, Cappai A, Citterio E, Tarelli G (2013). “Hamartoma of mature cardiac myocytes in adults and young: case report and literature review”. Int. J. Cardiol. 163 (2): e28–30. doi:10.1016/j.ijcard.2012.08.052. PMID 23041004.
- ↑ 3.0 3.1 Colović N, Cemerikić V, Colović R, Zogović S, Stojković M (2000). “[Hamartoma of the spleen]”. Srp Arh Celok Lek. 128 (9–10): 331–4. PMID 11255688.
- ↑ Tsitouridis I, Michaelides M, Tsitouridis K, Davidis I, Efstratiou I (January 2010). “Symptomatic splenoma (hamartoma) of the spleen. A case report”. Hippokratia. 14 (1): 54–6. PMC 2843574. PMID 20411063.
- ↑ Silverman ML, LiVolsi VA (August 1978). “Splenic hamartoma”. Am. J. Clin. Pathol. 70 (2): 224–9. PMID 696681.
- ↑ Iozzo RV, Haas JE, Chard RL (August 1980). “Symptomatic splenic hemartoma: a report of two cases and review of the literature”. Pediatrics. 66 (2): 261–5. PMID 7402811.
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