Hemorrhagic diathesis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Bleeding tendency; haemostasis abnormality; hemorrhagic diathesis; bleeding diathesis

Overview

Bleeding diathesis is an unusual susceptibility to bleeding (hemorrhage) due to a defect in the system of coagulation. Several types are distinguished, ranging from mild to lethal.

Causes

Common Causes

Anticoagulation therapy
Hepatopathies
Hereditary coagulopathies
Thrombocyte impairment
Vitamin K deficiency

Causes by Organ System

Cardiovascular	Anaphylactic shock, Bacterial endocarditis, Cyanotic cardiac vitium, Diffuse intravascular coagulation, Large vascular prostheses, Marfan’s syndrome, Myocardial infarction, Vascular hemostatic disorder, Vascular purpura, Vasculitis,
Chemical/Poisoning	Bothrop venom, Rattlesnake venom, Viper venom
Dental	No underlying causes
Dermatologic	Henoch-schonlein purpura, Measles, Nonthrombocytopenic purpura, Osler’s disease, Scurvy, Senile-atrophic senilis
Drug Side Effect	Anti-aggregation with aspirin, Anticoagulation inhibitors, Cobimetinib, Epoprostenol, Factor viii inhibitors, Propylthiouracil, Ramucirumab, Therapy with cholestyramin, Warfarin
Ear Nose Throat	No underlying causes
Endocrine	Amyloidosis, Chronic hypercortisolism, Cushing’s syndrome, Hermansky-pudlak syndrome,
Environmental	No underlying causes
Gastroenterologic	Acute pancreatitis, Biliary cirrhosis, Cirrhosis, Faulty intestinal flora, Liver failure, Severe gastrointestinal bleeding, Severe hepatopathy, Splenomegaly with portal hypertension
Genetic	Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Hematologic	Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Iatrogenic	Fibrinolysis therapy, Fibrinolytic fission products, Graft vs. host disease, Grey platelet syndrome, Large operations, Large vascular prostheses,
Infectious Disease	Bacterial endocarditis, Bacterial meningitis, Cephalosporins, Dengue hemorrhagic fever, Dengue shock syndrome, Diptheria, Influenza, Leptospirosis, Malaria, Measles, Rickettsia, Scarlet fever, Scurvy, Sepsis, Syphilis, Toxoplasmosis, Varicella
Musculoskeletal/Orthopedic	Myelodysplasia, Myeloproliferative syndrome
Neurologic	Bacterial meningitis, Cranio cerebral trauma, Large aneurysms, Osler’s disease
Nutritional/Metabolic	Avitaminosis c, Cirrhosis, Dietary deficiencies, Malabsorption, Parenteral nutrition, Vitamin k deficiency
Obstetric/Gynecologic	Amniotic fluid embolism, Intrauterine embryo death, Parenteral nutrition, Premature placenta ablation, Septic abortion
Oncologic	Carcinomas, Leukemia, Myelodysplasia, Myeloproliferative syndrome
Ophthalmologic
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Anaphylactic shock
Renal/Electrolyte	Lactic acidosis, Renal failure, Uremia
Rheumatology/Immunology/Allergy	Cystic fibrosis, Dysfibrinogenemia
Sexual	Syphilis
Trauma	Burns, Cranio cerebral trauma, Hypothermia, Intrauterine embryo death
Urologic	Uremia
Miscellaneous	No underlying causes

Causes In Alphabetical Order. ^[1] ^[2]

References

↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

Template:WikiDoc Sources

[1] Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016

[2] Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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