Hemosiderosis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Based on the duration of symptoms, pulmonary hemosiderosis may be classified as either acute or chronic phase.Pulmonary hemosiderosis may be classified into three groups based on disease characteristic: first group with circulating anti-glomerular basement membrane (anti-GBM) antibodies, second group, with immune complex disease, and the third group without known immunologic association or (IPH).

Based on the duration of symptoms, pulmonary hemosiderosis may be classified as either acute or the chronic phase.

• In the acute phase, patients present with sudden onset of severe dyspnea and hemoptysis, which, if not treated immediately, could be fatal.
• In the chronic phase, some children may present with weight loss, and failure to thrive or hypoxemic respiratory failure.

IPH may be classified into three groups based on disease characteristic:^[1]

• Group 1 pulmonary hemosiderosis involves PH with circulating anti-GMB antibodies which affecting the capillary system.
• Group 2 pulmonary hemosiderosis involves PH with an immune complex disease such as systemic lupus erythematosus (SLE).
• Group 3 pulmonary hemosiderosis involves no demonstrable immune system involvement.

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