Hemosiderosis differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Idiopathic pulmonary hemosiderosis must be differentiated from other diseases that cause alveolar hemorrhage, such as those include infectious etiologies( ARDS, Streptococcus pneumonia, Staphylococcus aureus, and legionella, influenza A and Pneumocystis jirovecii), rheumatic diseases such as systemic lupus erythematosus, antiphospholipid antibody syndrome, Goodpasture disease, microscopic granulomatous polyangiitis, and mixed cryoglobulinemias, drug-induced injury in medications such as medication such as amiodarone, nitrofurantoin, and infliximab, Penicillamine, or from thromboembolic disease, bleeding disorders, and neoplasms.

Idiopathic pulmonary hemosiderosis must be differentiated from other diseases that cause pulmonary hemorrhage and pulmonary hemosiderosis such as:^[1]

• Infectious etiologies which can cause pulmonary hemorrhage ( ARDS, Streptococcus pneumoniae, Staphylococcus aureus, and legionella, influenza A, and pneumocystis jirovecii)
• Rheumatic diseases such as systemic lupus erythematosus, antiphospholipid antibody syndrome, Goodpasture disease, microscopic and granulomatous polyangiitis, and mixed cryoglobulinemias
• Drug-induced injury in medications such as:
  • Amiodarone
  • Nitrofurantoin
  • Infliximab
  • Penicillamine
• Thromboembolic disease such as von Willebrand disease, thrombocytopenia, pulmonary embolism, pulmonary infarction
• Bleeding disorders
• Lung cancers

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