Henoch-Schönlein purpura causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The common causes of Henoch-Schönlein purpura (HSP) are infections, medications, hypersensitivity, vaccinations, genetics etc.

Common causes
- Infections–
- Medications
- Hypersensitivity
- Vaccinations– certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.
Rare causes
- Genetics– very rarely HSP can occur in twins and within the family
- Other triggers Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
Allergic reaction to foods may cause HSP.
Very rarely HSP can occur in twins and within the family.

↑ Davin JC, Coppo R (October 2014). “Henoch-Schönlein purpura nephritis in children”. Nat Rev Nephrol. 10 (10): 563–73. doi:10.1038/nrneph.2014.126. PMID 25072122.
↑ Micheletti RG, Werth VP (2015). “Small vessel vasculitis of the skin”. Rheum. Dis. Clin. North Am. 41 (1): 21–32, vii. doi:10.1016/j.rdc.2014.09.006. PMID 25399937.
↑ Zhdanova LV, Patrushev LI, Dolgikh VV, Bimbaev AB, Khoĭkova O (2014). “[The contribution of genes polymorphism of thrombophilia in clinical variability of hemorrhagic vasculitis]”. Vestn. Akad. Med. Nauk SSSR (in Russian) (3–4): 61–4. PMID 25306598. Vancouver style error: initials (help)
↑ Rigante D, Castellazzi L, Bosco A, Esposito S (August 2013). “Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?”. Autoimmun Rev. 12 (10): 1016–21. doi:10.1016/j.autrev.2013.04.003. PMID 23684700.
↑ Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B (July 2015). “IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects”. Autoimmun Rev. 14 (7): 579–85. doi:10.1016/j.autrev.2015.02.003. PMID 25688001.
↑ Pillebout E, Niaudet P (March 2008). “[Henoch-Schönlein purpura]”. Rev Prat (in French). 58 (5): 507–11. PMID 18524107.