Hepatocellular adenoma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Hepatocellular adenoma is more common in women in Western countries where they are exposed to higher doses of oral contraceptives. The estimated incidence is 3 per 100,000 individuals/year and is 3 to 4 per 100,000 individuals with long term history of oral contraceptive use. It is more common in women of childbearing age who take oral contraceptives and can rarely occur in men who take long term anabolic androgenic steroids.

• The estimated incidence of hepatocellular adenoma is 3 per 100,000 individuals/year.^[1][2][3]
• The annual incidence is substantially higher with long term oral contraceptive use, estimated at 3 to 4 per 100,000 individuals, but may be less with newer oral contraceptives.

• Prevalence of hepatocellular adenoma is difficult to asses because of the large proportion of adenomas not presenting with conventional symptoms.
• The prevalence of hepatocellular adenoma was increased in the 1970s following the introduction of oral contraception in Western countries.^[4]

• The hepatocellular adenoma is more common in women of childbearing age who take oral contraceptives.^[5][6]

• The hepatocellular adenoma is more common in women of childbearing age who take oral contraceptives.^[6]
• It can also rarely develop in men with long term anabolic androgenic steroids use.^[7]

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