Hepatocellular adenoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Small hepatocellular adenomas are generally asymptomatic. Typical clinical manifestations include spontaneous rupture or hemorrhage leading to acute abdominal pain with progression to hypotension and even death. Patients with hepatocellular adenoma typically have a history of oral contraceptive use (females) and long term anabolic steroids use (males).

• Patients with hepatocellular adenoma present with history of abdominal pain/discomfort.
• Obesity, being a risk factor, can mask the physical examination findings of hepatocellular adenoma.

• Small hepatocellular adenomas are generally asymptomatic.^[1][2][3]
• Abdominal pain is the most common presenting symptom in some patients, and the pain is usually related to tumoral hemorrhage.
• Right upper quadrant abdominal fullness or discomfort is present in 40% of the cases due to mass effect.
• Eventually, spontaneous rupture or hemorrhage may occur, leading to acute abdominal pain with progression to hypotension and even death.
• Patients with hepatocellular adenoma typically have a history of oral contraceptive use (females) and long term anabolic steroids use (males).^[4][5]

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