High cholesterol causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Elevated cholesterol level can be caused by a wide variety of factors which include: genetic (e.g. familial hypercholesterolemia); endocrine (e.g. diabetes mellitus ); drug side effect (e.g. beta blockers, thiazide diuretics); kidney disease (e.g. nephrotic syndrome, chronic kidney disease), and many other factors.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. High cholesterol in itself is not a life threatening condition.

Common Causes

Causes by Organ System

Cardiovascular	Alagille syndrome, familial hypercholesterolemia
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Estrogens, everolimus, olanzapine, sirolimus, temsirolimus, thiazide diuretics , tofacitinib
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, hypothyroidism, metabolic syndrome, polycystic ovary syndrome
Environmental	No underlying causes
Gastroenterologic	Glycogenosis type 3, glycogenosis type 6, Niemann-Pick disease type B , primary biliary cirrhosis, Stauffer syndrome, Zieve’s syndrome
Genetic	Analbuminaemia, apolipoprotein B deficiency, Apolipoprotein C2 deficiency, apoliprotein E deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial hypercholesterolemia, familial hyperlipoproteinemia type 5, glycogen storage disease type 1a, glycogenosis type 3, glycogenosis type 6, lecithin cholesterol acyltransferase deficiency, lipoprotein lipase deficiency, Niemann-Pick disease type B
Hematologic	Zieve’s syndrome
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	Berardinelli–Seip syndrome
Neurologic	Apoliprotein E deficiency
Nutritional/Metabolic	Analbuminaemia, Berardinelli–Seip syndrome, diabetes mellitus, glycogenosis type 3, glycogenosis type 6, metabolic syndrome, Niemann-Pick disease type B, obesity, Zieve’s syndrome
Obstetric/Gynecologic	Polycystic ovary syndrome, pregnancy
Oncologic	No underlying causes
Ophthalmologic	Alström syndrome
Overdose/Toxicity	No underlying causes
Psychiatric	Binge eating disorder
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic kidney disease, nephrotic syndrome
Rheumatology/Immunology/Allergy	Hashimoto’s thyroiditis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Lack of physical inactivity

Causes in Alphabetical Order

References

↑ Kasiske BL, Ma JZ, Kalil RS, Louis TA (1995). “Effects of antihypertensive therapy on serum lipids”. Ann Intern Med. 122 (2): 133–41. PMID 7992988.
↑ Boers M, Nurmohamed MT, Doelman CJ, Lard LR, Verhoeven AC, Voskuyl AE; et al. (2003). “Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis”. Ann Rheum Dis. 62 (9): 842–5. PMC 1754645. PMID 12922956.
↑ Genest JJ, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH; et al. (1992). “Familial lipoprotein disorders in patients with premature coronary artery disease”. Circulation. 85 (6): 2025–33. PMID 1534286.

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[pmid7992988-1] Kasiske BL, Ma JZ, Kalil RS, Louis TA (1995). “Effects of antihypertensive therapy on serum lipids”. Ann Intern Med. 122 (2): 133–41. PMID 7992988.

[pmid12922956-2] Boers M, Nurmohamed MT, Doelman CJ, Lard LR, Verhoeven AC, Voskuyl AE; et al. (2003). “Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis”. Ann Rheum Dis. 62 (9): 842–5. PMC 1754645. PMID 12922956.

[pmid1534286-3] Genest JJ, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH; et al. (1992). “Familial lipoprotein disorders in patients with premature coronary artery disease”. Circulation. 85 (6): 2025–33. PMID 1534286.

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