Hirschsprung's disease epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

The incidence of Hirschsprung’s disease is 20 in every 100,000 newborns. It is three times more common in Asian Americans than the rest of the population. Males are more commonly affected than females.

• The incidence of Hirschsprung’s disease is 20 in every 100,000 newborns.^[1]
• The incidence is estimated to be lower in the United States at 7 in every 100,000 newborns.

• Hirschsprung’s disease is three times more common in Asian Americans than the rest of the population.^[2]

• Males are more commonly affected by Hirschsprung’s disease than females.
• The male to female ratio is approximately 4:1.
• For total aganglionic colon, the male to female ratio is 1:1.^[2]