Human parainfluenza viruses medical therapy
Overview
Antimicrobial therapy is indicated in infections caused by Parainfluenza virus. The drug of choice is Ribavirin.
Medical Therapy
Antimicrobial regimen
- Parainfluenza virus[1]
- 1. Adults
- Preferred regimen: Ribavirin PO/IV 10 mg/kg q8h
- Day 1: Start with 600 mg loading dose THEN 200 mg q8h
- Day 2: 400 mg q8h
- Day 3: Increase the dose to a maximum of 10 mg/kg q8h
- 1.1 In case of adverse events
- Preferred regimen: Decrease dose or discontinue Ribavirin
- 1.2 Creatinine clearance
- 30–50 mL/min: Ribavirin PO/IV maximal 200 mg q8h
- 10–30 mL/min: No recommendation can be given
References
- ↑ Hirsch HH, Martino R, Ward KN, Boeckh M, Einsele H, Ljungman P (2013). “Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus”. Clin Infect Dis. 56 (2): 258–66. doi:10.1093/cid/cis844. PMC 3526251. PMID 23024295.
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