Hypergammaglobulinemia classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Hypergammaglobulinemia may be classified into the following:
- Hyper Ig M associated hypergammaglobulinemias
- Hyper Ig D syndrome
- Hyper Ig E syndrome
Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:^[1]^[2]


Type	Gene involved	Mode of inheritance

Type 1	Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene encoding CD40L	X-linked recessive
Type 2	Activation-Induced Cytidine Deaminase (AICDA) gene	Autosomal recessive
Type 3	CD40 gene	Autosomal recessive
Type 4	Not yet known
Type 5	Gene encoding Uracil-DNA glycosylase	Autosomal recessive

↑ Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016
↑ Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016