Hypermagnesemia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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• Since magnesium is excreted through the kidneys, renal failure can result in hypermagnesemia. The most important cause however is suppletion.
• Hemolysis, magnesium concentration in erythrocytes is approximately three times greater than in serum, therefore hemolysis can increase plasma magnesium. Hypermagnesemia is expected only in massive hemolysis.
• Renal insufficiency, excretion of magnesium becomes impaired when creatinine clearance falls below 30 ml/min. However, hypermagnesemia is not a prominent feature of renal insufficiency unless magnesium intake is increased.
• Other conditions that can predispose to mild hypermagnesemia are diabetic ketoacidosis, adrenal insufficiency, hyperparathyroidism and lithium intoxication.

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