Hypogonadism historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Hypogonadism was first reported by Dr. Maestre de San Juan in a case of small testes and loss of smelling sensation. Dr. Kallmann in 1944 identified this syndrome which was named on him after that. Dr. de Morsier reported various cases of hypogonadism with absent olfactory bulbs in the 1950s.

Historical perspective

In 1856, Dr. Maestre de San Juan was the first one to report a case combining small testes (hypogonadism) and loss of smelling sense in a patient.
In 1944, Dr. Kallmann was the first to identify a case combining hypogonadism and anosmia as a syndrome which was named on him after then. He held a study showing the correlation between anosmia and hypogonadism in different families.^[1]
In the 1950s, Dr. de Morsier reported various cases of patients with hypogonadism and with absent olfactory bulbs as well. After which, hypogonadism has been described as gonadotropin hormones deficiency.

References

↑ Dodé C, Hardelin JP (2009). “Kallmann syndrome”. Eur J Hum Genet. 17 (2): 139–46. doi:10.1038/ejhg.2008.206. PMC 2986064. PMID 18985070.

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[pmid18985070-1] Dodé C, Hardelin JP (2009). “Kallmann syndrome”. Eur J Hum Genet. 17 (2): 139–46. doi:10.1038/ejhg.2008.206. PMC 2986064. PMID 18985070.

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