Hypophosphatemia pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Hypophosphatemia is caused by the following three mechanisms:

• Inadequate intake (often unmasked in refeeding after long-term low phosphate intake)
• Increased excretion (e.g. in hyperparathyroidism)
• Shift from extracellular to intracellular space (seen in treatment of diabetic ketoacidosis, refeeding, short-term increases in cellular demand (e.g., hungry bones syndrome) and acute respiratory alkalosis)

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