IL13RA2
Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[1]
Function
IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[1]
See also
References
Further reading
- Andrews AL, Nasir T, Bucchieri F, et al. (1996). “IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts”. J. Allergy Clin. Immunol. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
- Caput D, Laurent P, Kaghad M, et al. (1996). “Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain”. J. Biol. Chem. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
- Zhang JG, Hilton DJ, Willson TA, et al. (1997). “Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains”. J. Biol. Chem. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
- Gauchat JF, Schlagenhauf E, Feng NP, et al. (1997). “A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor”. Eur. J. Immunol. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652.
- Guo J, Apiou F, Mellerin MP, et al. (1997). “Chromosome mapping and expression of the human interleukin-13 receptor”. Genomics. 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
- Donaldson DD, Whitters MJ, Fitz LJ, et al. (1998). “The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1”. J. Immunol. 161 (5): 2317–24. PMID 9725226.
- Osawa M, Miyoshi S, Copeland NG, et al. (2000). “Characterization of the mouse interleukin-13 receptor alpha1 gene”. Immunogenetics. 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391.
- Kawakami K, Takeshita F, Puri RK (2001). “Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain”. J. Biol. Chem. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
- Daines MO, Hershey GK (2002). “A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma”. J. Biol. Chem. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
- Okano F, Storkus WJ, Chambers WH, et al. (2002). “Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain”. Clin. Cancer Res. 8 (9): 2851–5. PMID 12231526.
- Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, et al. (2003). “Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein”. J. Invest. Dermatol. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- David M, Bertoglio J, Pierre J (2003). “TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression”. Ann. N. Y. Acad. Sci. 973: 207–9. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861.
- Wu AH, Low WC (2003). “Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter”. Neuro-oncology. 5 (3): 179–87. doi:10.1215/s1152851702000510. PMC 1920687. PMID 12816724.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). “The DNA sequence of the human X chromosome”. Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Arima K, Sato K, Tanaka G, et al. (2005). “Characterization of the interaction between interleukin-13 and interleukin-13 receptors”. J. Biol. Chem. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
- Fichtner-Feigl S, Strober W, Kawakami K, et al. (2006). “IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis”. Nat. Med. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802.
- Daines MO, Tabata Y, Walker BA, et al. (2006). “Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling”. J. Immunol. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
- Kioi M, Kawakami M, Shimamura T, et al. (2006). “Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy”. Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988.
- Granel B, Allanore Y, Chevillard C, et al. (2007). “IL13RA2 gene polymorphisms are associated with systemic sclerosis”. J. Rheumatol. 33 (10): 2015–9. PMID 16981293.
External links
- IL13RA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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