Idiopathic thrombocytopenic purpura history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

ITP is chronic in adults^[1] and the probability of remission is 20–40%.^[2] , ITP patients suffer from bruising, petechiae, nosebleeds and bleeding gums may occur if the platelet count is below 20,000,^[3] compared to a normal range of 150,000–400,000 per mm³.

Evans syndrome can occur in ~1% of cases and manifests by an autoimmune (Coombs +) hemolytic anemia with ITP.

Symptoms include:

Abnormally heavy menstruation
Bleeding into the skin causing a characteristic skin rash that looks like pinpoint red spots (petechial rash), purpura
Easy bruising
Nosebleed or bleeding in the mouth
intracranial hemorrhage

References

↑ Cines DB, Blanchette VS (2002). “Immune thrombocytopenic purpura”. N. Engl. J. Med. 346 (13): 995–1008. doi:10.1056/NEJMra010501. PMID 11919310.
↑ Stevens W, Koene H, Zwaginga JJ, Vreugdenhil G (2006). “Chronic idiopathic thrombocytopenic purpura: present strategy, guidelines and new insights”. The Netherlands journal of medicine. 64 (10): 356–63. PMID 17122451.
↑ Cines DB, McMillan R (2005). “Management of adult idiopathic thrombocytopenic purpura”. Annu. Rev. Med. 56: 425–42. doi:10.1146/annurev.med.56.082103.104644. PMID 15660520.

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[pmid11919310-1] Cines DB, Blanchette VS (2002). “Immune thrombocytopenic purpura”. N. Engl. J. Med. 346 (13): 995–1008. doi:10.1056/NEJMra010501. PMID 11919310.

[pmid17122451-2] Stevens W, Koene H, Zwaginga JJ, Vreugdenhil G (2006). “Chronic idiopathic thrombocytopenic purpura: present strategy, guidelines and new insights”. The Netherlands journal of medicine. 64 (10): 356–63. PMID 17122451.

[pmid15660520-3] Cines DB, McMillan R (2005). “Management of adult idiopathic thrombocytopenic purpura”. Annu. Rev. Med. 56: 425–42. doi:10.1146/annurev.med.56.082103.104644. PMID 15660520.

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