Immune Thrombocytopenia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Barkhordarian, M.D.[2]

Disease name] may be caused by [cause1], [cause2], or [cause3].

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Immune thrombocytopenia has been classified to two groups; Primary or Secondary. Common causes of secondary ITP include SLE, antiphospholipid syndrome, infectious disease and thyroid disease. There are also some less common cause which include Evans syndrome and lymphoproliferative disease.

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The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].

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The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.

• Immune thrombocytopenia include primary and secondary.
• The cause of Primary immune thrombocytopenia is unknown. It occurs by autoantibodies binding to platelet surface then captured and destructed by macrophages in spleen and liver.

Common causes of secondary immune thrombocytopenia may include:

• systemic lupus erythematous
• antiphospholipid syndrome
• Thyroid disease ( hypothyroidism, hyperthyroidism, immune Thyroid disease)
• Drug induced thrombocytopenia ( such as Heparin induced thrombocytopenia)
• Infectious disease (HIV, HCV, Helicobacter pylori )

Less common causes of [disease name] include:

• Evans syndrome (immune anemia , immune thrombocytopenia and immune neutropenia)
• Posttransfusion purpura ( In caucasian woman within 7 days of blood product transfusion due to developing antibody against HPA1b epitope.)
• Lymphoproliferative disease ( CLL (difficult to distinguish from marrow infiltration and splenomegaly), Large granular lymphocytic leukemia (clonal sequestration of megakaryocytic.) and Hodgkin lymphoma.)^[1]

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