Immune Thrombocytopenia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Barkhordarian, M.D.[2]

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of ITP is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of ITP include environmental, genetic and viral. Genetic risk factors includes mutations in single nucleotide polymorphism and variety of interleukins. The most common viral and environmental risk factors include infection with HIV and Helicobacter pylori.

OR

Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

• Common risk factors in the development of Immune thrombocytopenia may be environmental, genetic, and viral.
• Genetic risk factors include:
  • • association between ITP and single nucleotide polymorphism (SNP)
    • Polymorphism in genes of Interleukin-1, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-<math>\alpha</math>, TNF-<math>\beta</math> and INF-<math>\gamma</math>. ^[1]
• Environmental and viral risk factors include exposure with HIV, Helicobacter pylori, HCV, CMV, and EBV.
• Common non-modifiable risk factors in the development of Immune thrombocytopenia in children include:
  • older age
  • less thrombocytopenia at the initial diagnosis
  • gradual onset of symptoms
  • lack of platelet count recovery at four weeks
  • lack of proceeding infection or vaccination as a trigger.^[2]

• Less common risk factors in the development of [disease name] include:
  • [Risk factor 1]
  • [Risk factor 2]
  • [Risk factor 3]

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