Immunophenotyping

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Immunophenotyping is a technique notably used in the diagnosis of leukemia. It involves the labelling of white blood cells with antibodies directed against surface proteins on their membrane. By choosing appropriate antibodies, the origin of leukemic cells can be accurately determined. The labelled cells are processed in a flow cytometer, a laser-based instrument capable of analyzing thousands of cells per second. The whole procedure can be performed on cells from the blood, bone marrow or spinal fluid in a matter of a few hours.

• British Society for Haematology guidelines accessed July 31, 2006
• Immunophenotyping Lymphomas, University of Medicine & Dentistry of New Jersey
• Immunophenotyping at the US National Library of Medicine Medical Subject Headings (MeSH)

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