Insulinoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

A positive long history of frequent episodes of altered mental status/confusion, visual disturbances and sweating is suggestive of insulinoma. The most common symptoms of insulinoma include altered mental status/confusion, visual disturbances like blurred vision/diplopia, sweating, hyperphagia and coma. Less common symptoms of insulinoma include palpitations, seizures, tremors, behavioral disturbances and weakness.

Insulinoma patients usually present with history of hypoglycemic episodes occurring over time with a recent increase in frequency and without any other cause known to cause hypoglycemia like exogenous insulin and hypoglycemic agents. The following are the history and symptoms of insulinoma:

Patients with insulinoma may have a positive history of:

• Frequent episodes of altered mental status/confusion
• Visual disturbances
• Sweating
• Negative history for exogenous insulin or oral hypoglycemic agents such as Sulfonylureas

Common symptoms of insulinoma include: ^[1][2]

• Altered mental status/confusion
• Visual disturbances like blurred vision/diplopia
• Sweating
• Hyperphagia
• Coma

Less common symptoms of insulinoma include

• Palpitations
• Seizures
• Tremors
• Behavioral disturbances
• Weakness

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