Ionotropic effect

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

An ionotropic effect is a special kind of effect of a hormone on its target. The hormone activates or deactivates ionotropic receptors (ligand-gated ion channels). The effect can be either positive or negative, whether the effect is a depolarization or a hyperpolarization respectively.

Examples

Noradrenaline has a positive ionotropic effect on heart muscle, when binding to beta-1 adrenergic receptors on this tissue^[1]. The result is an increased cardiac output.

References

↑ Neuroscience (Purves), Third Edition, table 20:2

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[purves-1] Neuroscience (Purves), Third Edition, table 20:2

[1]