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Iron deficiency anemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]

Overview

Iron deficiency anemia may be asymptomatic, or present with very few symptoms or very severe weakness depending on the severity of anemia.

History and Symptoms

History

The patients of iron deficiency anemia may present with a positive history of[1][2][3][4][5][6][7]:

Common symptoms

  • Sore tongue

Less common symptoms

Age Specific Presentation

Infants (age 0-12 months) and Preschool Children (age 1-5 years)

  • Iron-deficiency anemia was defined as a Hb concentration of less than or equal to 10.0 g/dL or less than or equal to 10.5 g/dL
  • Developmental delays
  • Behavioral disturbances[8] (e.g., decreased motor activity, social interaction, and attention to tasks)
  • Iron-deficiency anemia also contributes to lead poisoning in children by increasing the gastrointestinal tract’s ability to absorb heavy metals, including lead.

Adults (persons aged greater than or equal to 18 years)

  • Decreased functional capacity

Pregnant Female

  • Iron-deficiency anemia during the first two trimesters of pregnancy is associated with a twofold increased risk for preterm delivery and a threefold increased risk for delivering a low-birthweight baby.

Center for disease control and prevention

References

  1. Price EA, Mehra R, Holmes TH, Schrier SL (2011). “Anemia in older persons: etiology and evaluation”. Blood Cells Mol Dis. 46 (2): 159–65. doi:10.1016/j.bcmd.2010.11.004. PMID 21208814.
  2. Cook JD, Skikne BS (1989). “Iron deficiency: definition and diagnosis”. J Intern Med. 226 (5): 349–55. PMID 2681511.
  3. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L (2016). “Iron deficiency anaemia”. Lancet. 387 (10021): 907–16. doi:10.1016/S0140-6736(15)60865-0. PMID 26314490.
  4. Camaschella C (2015). “Iron deficiency: new insights into diagnosis and treatment”. Hematology Am Soc Hematol Educ Program. 2015: 8–13. doi:10.1182/asheducation-2015.1.8. PMID 26637694.
  5. Rector WG (1989). “Pica: its frequency and significance in patients with iron-deficiency anemia due to chronic gastrointestinal blood loss”. J Gen Intern Med. 4 (6): 512–3. PMID 2585159.
  6. Simpson E, Mull JD, Longley E, East J (2000). “Pica during pregnancy in low-income women born in Mexico”. West J Med. 173 (1): 20–4, discussion 25. PMC 1070964. PMID 10903283.
  7. Corazza GR, Valentini RA, Andreani ML, D’Anchino M, Leva MT, Ginaldi L; et al. (1995). “Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia”. Scand J Gastroenterol. 30 (2): 153–6. PMID 7732338.
  8. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH; et al. (2013). “Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study”. BMC Psychiatry. 13: 161. doi:10.1186/1471-244X-13-161. PMC 3680022. PMID 23735056.

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