KLRA1

Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.^[1]^[2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.

The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).^[3]^[4]

References

↑ Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S (January 2005). “The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex”. Eur. J. Immunol. 35 (1): 261–72. doi:10.1002/eji.200425429. PMID 15593300.
↑ Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG (November 2006). “Ly49B is expressed on multiple subpopulations of myeloid cells”. J. Immunol. 177 (9): 5840–51. doi:10.4049/jimmunol.177.9.5840. PMID 17056508.
↑ Barten R, Trowsdale J (July 1999). “The human Ly-49L gene”. Immunogenetics. 49 (7–8): 731–4. doi:10.1007/s002510050675. PMID 10369937.
↑ Hao L, Klein J, Nei M (February 2006). “Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals”. Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3192–7. doi:10.1073/pnas.0511280103. PMC 1413923. PMID 16492762.

External links

Ly-49+antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

[pmid15593300-1] Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S (January 2005). “The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex”. Eur. J. Immunol. 35 (1): 261–72. doi:10.1002/eji.200425429. PMID 15593300.

[pmid17056508-2] Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG (November 2006). “Ly49B is expressed on multiple subpopulations of myeloid cells”. J. Immunol. 177 (9): 5840–51. doi:10.4049/jimmunol.177.9.5840. PMID 17056508.

[pmid10369937-3] Barten R, Trowsdale J (July 1999). “The human Ly-49L gene”. Immunogenetics. 49 (7–8): 731–4. doi:10.1007/s002510050675. PMID 10369937.

[pmid16492762-4] Hao L, Klein J, Nei M (February 2006). “Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals”. Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3192–7. doi:10.1073/pnas.0511280103. PMC 1413923. PMID 16492762.

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