Kidney stone laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Laboratory findings consistent with the diagnosis of nephrolithiasis include hypercalcemia, hypercalciuria, hyperoxaluria, hypocitraturia, hyperuricemia and hyperuricosuria

Laboratory Findings

Laboratory findings consistent with the diagnosis of nephrolithiasis include:

The urine calcium/creatinine ratio should be less than 0.14^[1]. Higher values suggest hypercalcuria.

The urine calcium to urinary citrate ratio (UCa/Ucit) is not well studied, but should maybe be < 0.7^[2] Higher values may suggest hyperparathyroidism.

References

↑ Foley, Kevin F.; Boccuzzi, Lorenzo (2010). “Urine Calcium: Laboratory Measurement and Clinical Utility”. Laboratory Medicine. 41 (11): 683–686. doi:10.1309/LM9SO94ZNBHEDNTM. ISSN 0007-5027.
↑ Gafni RI, Langman CB, Guthrie LC, Brillante BA, James R, Yovetich NA; et al. (2018). “Hypocitraturia Is an Untoward Side Effect of Synthetic Human Parathyroid Hormone (hPTH) 1-34 Therapy in Hypoparathyroidism That May Increase Renal Morbidity”. J Bone Miner Res. 33 (10): 1741–1747. doi:10.1002/jbmr.3480. PMID 29878514.

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[Foley_Boccuzzi_2010_pp._683–686-1] Foley, Kevin F.; Boccuzzi, Lorenzo (2010). “Urine Calcium: Laboratory Measurement and Clinical Utility”. Laboratory Medicine. 41 (11): 683–686. doi:10.1309/LM9SO94ZNBHEDNTM. ISSN 0007-5027.

[pmid29878514-2] Gafni RI, Langman CB, Guthrie LC, Brillante BA, James R, Yovetich NA; et al. (2018). “Hypocitraturia Is an Untoward Side Effect of Synthetic Human Parathyroid Hormone (hPTH) 1-34 Therapy in Hypoparathyroidism That May Increase Renal Morbidity”. J Bone Miner Res. 33 (10): 1741–1747. doi:10.1002/jbmr.3480. PMID 29878514.

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