Klebsiella granulomatis
This page is about microbiologic aspects of the organism(s). For clinical aspects of the disease, see Donovanosis.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.;
Overview
Klebsiella granulomatis, originally classified as Calymmatobacterium granulomatis, is a fastidious Gram-negative pleomorphic bacteria causing donovanosis, a gential ulcer disease.
Organism
- Aragão and Vianna classified the bacteria causing donovanosis as Calymmatobacterium granulomatis in 1913. However, DNA sequencing of 16S rRNA and phoE genes revealed similarity to Klebsiella.[1]
- There is 99% homology between the etiologic agent of donovanosis and members of Klebsiella.[2]
- A proposal has been put forth to reclassify the bacteria to Klebsiella granulomatis.
- K. granulomatis morphology:[3]
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 μm
- May or may not be capsulated
- Non-motile
Human Pathogen
- K. granulomatis is an obligate, intracellular human pathogen.
- K. granulomatis is typically transmitted through sexual contact but may also be transmitted through direct contact and fecal contamination.[4]
Gallery
-
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/b/ba/Granuloma_inguinale12.jpeg)
This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5] -
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/e/ef/Enterobacteria28.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5] -
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/d/da/Enterobacteria56.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5] -
![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/images/f/f6/Enterobacteria27.jpeg)
Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AGranuloma_inguinale12.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria28.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria56.jpeg)
![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](https://www.wikidoc.org/index.php/File%3AEnterobacteria27.jpeg)
References
- ↑ Velho, Paulo Eduardo Neves Ferreira; Souza, Elemir Macedo de; Belda Junior, Walter (2008). “Donovanosis”. Brazilian Journal of Infectious Diseases. 12 (6). doi:10.1590/S1413-86702008000600015. ISSN 1413-8670.
- ↑ Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J; et al. (1997). “Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells”. J Clin Microbiol. 35 (11): 2915–7. PMC 230086. PMID 9350758.
- ↑ Richens J (1991). “The diagnosis and treatment of donovanosis (granuloma inguinale)”. Genitourin Med. 67 (6): 441–52. PMC 1194766. PMID 1774048.
- ↑ O’Farrell N (2002). “Donovanosis”. Sex Transm Infect. 78 (6): 452–7. PMC 1758360. PMID 12473810.
- ↑ 5.0 5.1 5.2 5.3 “Public Health Image Library (PHIL)”.
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