Klinefelter's syndrome natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

In these patients, GSTs usually contain nonseminomatous elements, present at an earlier age, and seldom are testicular in location.

The syndrome increases the risk of:

• Attention-deficit hyperactivity disorder
• Autoimmune disorders such as lupus, rheumatoid arthritis, and Sjogren syndrome
• Breast cancer
• Depression
• Dyslexia
• 50 times greater risk of extragonadal germ cell tumor (a rare tumor)^[1]
• Learning disabilities, despite normal or high IQ
• Lung disease
• Osteoporosis
• Varicose veins

Enlarged teeth with a thinning surface (taurodontism) is very common in Klinefelter’s syndrome. It can be diagnosed by dental x-rays.

• Most patients have a normal, productive life.

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