Kyotorphin

Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain by Japanese scientists in 1979^[1]. Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine– (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing an Met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that it is lower in patients with persistent pain^[2].

Notes

↑ Takagi H, Shiomi H, Ueda and Amano H (1979) A novel analgesic dipeptide from bovine brain is a possible met-enkephalin releaser. Nature (Lond) 282: 410-412.
↑ K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H. (1991) Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain Masui. Nov;40(11):1686-90.

Template:WikiDoc Sources

[1] Takagi H, Shiomi H, Ueda and Amano H (1979) A novel analgesic dipeptide from bovine brain is a possible met-enkephalin releaser. Nature (Lond) 282: 410-412.

[2] K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H. (1991) Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain Masui. Nov;40(11):1686-90.

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