Leopard syndrome natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

In general, males are more affected than females. LEOPARD syndrome is not a life threatening diagnosis, cardiomyopathy and other pathologic findings involving the cardiovascular system may be a cause of death in those whose cardiac deformities are profound.

Natural History, Complications and Prognosis

Males are more likely than females to be affected with LEOPARD syndrome.^[1] LEOPARD syndrome is not a life threatening diagnosis, but Obstructive cardiomyopathy and other pathologic findings involving the cardiovascular system may be a cause of death in those whose cardiac deformities are profound. It is suggested that, once diagnosed, individuals be routinely followed by a cardiologist, endocrinologist, dermatologist, and other appropriate specialties as symptoms present.

References

↑ Voron DA, Hatfield HH, Kalkhoff RK (1976). “Multiple lentigines syndrome. Case report and review of the literature”. Am J Med. 60 (3): 447–56. PMID 1258892.

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[pmid1258892-1] Voron DA, Hatfield HH, Kalkhoff RK (1976). “Multiple lentigines syndrome. Case report and review of the literature”. Am J Med. 60 (3): 447–56. PMID 1258892.

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