Linitis plastica causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.

• Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.^[1]
• Somatic mutations in the CDH1 gene can occur by:
  • Hypermethylation
  • Loss of heterozygosity
  • Silencing mutations

• Lye ingestion
• Metastatic infiltration of the stomach by:
  • Lung cancer
  • Breast cancer
  • Non-Hodgkin lymphoma^[2]

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