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Liposarcoma medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Medical therapy for liposarcoma includes Chemotherapy, chemoradiation, immunotherapy, and targeted therapy.

Medical Therapy

Chemotherapy

Chemoradiation

  • Sometimes the targeted therapy is given along with radiation.
  • They may be given together or at different intervals.

Targeted Therapy

Immunotherapy

Drug Type of drug
Bevacizumab Targeted therapy
Celecoxib Targeted therapy
Crizotinib Targeted therapy
Dacarbazine Chemotherapy
Dasatinib Targeted therapy
Docetaxel Chemotherapy
Doxorubicin Chemotherapy
Epirubicin hydrochloride Chemotherapy
Everolimus Chemotherapy
Gemcitabine hydrochloride Chemotherapy
Ifosfamide Chemotherapy
Imatinib mesylate Targeted therapy
Interferon alpha 2B Immunotherapy
Mesna Chemotherapy
Methotrexate Chemotherapy
Nilotinib Chemotherapy
Paclitaxel Chemotherapy
Pazopanib Targeted therapy
Regorafenib Targeted therapy
Sorafenib tosylate Targeted therapy
Sirolimus Chemotherapy
Sulindac Chemotherapy
Sunitinib malate Targeted therapy
Tamoxifen citrate Targeted therapy
Temozolomide Chemotherapy
Toremifene citrate Targeted therapy
Vinblastine citrate Chemotherapy
Vinblastine tartrate Chemotherapy

Regimen

Drugs Dose
Doxorubicin Doxorubicin 75 mg/m2; 28 day cycle
Pegylated liposomal doxorubicin 40 – 50 mg/m2 ; 28 day cycle
AI regimen Doxorubicin 25 mg/m2, Ifosfamide 3 g/m2 21 day cycle
MAID regimen Doxorubicin 20 mg/m2, Ifosfamide 2.5 g/m2, Dacarbazine 300mg/m2 21 day cycle
AD regimen Doxorubicin 20 mg/m2, Dacarbazine 300 mg/m2; 21 day cycle
Metronomic cyclophosphamide Oral daily cyclophosphamide 50mg/day for 21 days on 28 day cycle
DocetaxelGemcitabine Gemcitabine 900 mg/m2 , Docetaxel 100 mg/m2 for 21 day cycle
Trabectedin Trabectedin 1.5 mg/m2 21 day cycle[2]

References

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