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Lymphoplasmacytic lymphoma MRI

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

There are no specific MRI findings associated with lymphoplasmacytic lymphoma. However, MRI of the brain, spinal cord and orbits is especially important while assessing hyperviscosity and for diagnosing Bing-Neel syndrome.

MRI

MRI brain coronal view shows diffuse meningeal enhancement in a patient with Bing-Neel syndrome. [https://openi.nlm.nih.gov/detailedresult.php?img=PMC4837273_CRIHEM2016-3931709.002&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=69 Source: Halperin D. et al, Whipps Cross Hospital, London E11 1NR, UK.
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Coronal T1-weighted (TR 600, TE 30) 3mm noncontrast sections through the inner ear in a patient with Waldenstrom macroglobulinemia with bilateral hearing loss. Arrows indicate hemorrhage within the labyrinth. [https://openi.nlm.nih.gov/detailedresult.php?img=PMC4891550_gr2&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=67 Source: Shibata DK. et al.
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Axial T1-weighted (TR 700, TE 30) 3mm noncontrast sections through the petrous bone in a patient with Waldenstrom macroglobulinemia with bilateral hearing loss. Arrows indicate T1 shortening within the labyrinth. [https://openi.nlm.nih.gov/detailedresult.php?img=PMC4891550_gr1&query=waldenstrom+macroglobulinaemia&it=xg&req=4&npos=66 Source: Shibata DK. et al.
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References

  1. ↑ O’Neil DS, Francescone MA, Khan K, Bachir A, O’Connor OA, Sawas A (2018). “A Case of Bing-Neel Syndrome Successfully Treated with Ibrutinib”. Case Rep Hematol. 2018: 8573105. doi:10.1155/2018/8573105. PMC 6136466. PMID 30228918.
  2. ↑ Minnema MC, Kimby E, D’Sa S, Fornecker LM, Poulain S, Snijders TJ; et al. (2017). “Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome”. Haematologica. 102 (1): 43–51. doi:10.3324/haematol.2016.147728. PMC 5210231. PMID 27758817.
  3. ↑ Tallant A, Selig D, Wanko SO, Roswarski J (2018). “First-line ibrutinib for Bing-Neel syndrome”. BMJ Case Rep. 2018. doi:10.1136/bcr-2018-226102. PMID 30279255.

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